Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6640936 | 0.75 | — | — | |
| SCHEMBL4449091 | 0.70 | CCR1 (0.37) | MEN1ALDH1A1GAAKMT2A | |
| SCHEMBL4441999 | 0.70 | GRM5 (0.36) | ALDH1A1GAA | |
| SCHEMBL5253609 | 0.69 | MEN1 (0.32) | MEN1ALDH1A1GAAKMT2A | |
| SCHEMBL620716 | 0.67 | MEN1 (0.40) | MEN1ALDH1A1GAAKMT2A | |
| SCHEMBL2125246 | 0.66 | MEN1 (0.34) | MEN1ALDH1A1GAAKMT2A | |
| SCHEMBL3352304 | 0.65 | MEN1 (0.33) | MEN1ALDH1A1GAAKMT2A | |
| SCHEMBL3345273 | 0.63 | — | — | |
| SCHEMBL13089143 | 0.62 | ALDH1A1 (0.34) | MEN1ALDH1A1GAAKMT2A | |
| SCHEMBL25497152 | 0.61 | TDP1 (0.34) | MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3182973-A1 | TRICYCLIC NITROGEN CONTAINING COMPOUNDS FOR TREATING NEISSERIA GONORRHOEA INFECTION | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2017-06-28 | — | — | EP | disclosed |
| WO-2016027249-A1 | TRICYCLIC NITROGEN CONTAINING COMPOUNDS FOR TREATING NEISSERIA GONORRHOEA INFECTION | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2016-02-25 | — | — | WO | disclosed |
| EP-2137196-A1 | TRICYCLIC NITROGEN CONTAINING COMPOUNDS AS ANTIBACTERIAL AGENTS | Glaxo Group Limited (GB) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008128942-A1 | TRICYCLIC NITROGEN CONTAINING COMPOUNDS AS ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |