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SCHEMBL4439716

SCHEMBL4439716

Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)c2ccc(Cc3ccc4cc(F)ccc4c3)[nH]c2=O)C(=O)O)c(C)c2c1OC(C)(C)CC2

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ F2 P00734 1/20 0.36
▸ PLG P00747 2/20 0.34
▸ F10 P00742 1/20 0.34
▸ PLAU P00749 1/20 0.34
▸ KLKB1 P03952 1/20 0.34
▸ FOLR2 P14207 1/20 0.31
▸ FOLR1 P15328 1/20 0.31
▸ GART P22102 1/20 0.31
▸ SLC19A1 P41440 1/20 0.31
▸ SLC46A1 Q96NT5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4439729 0.95 F2 (0.37) F2PLGF10PLAUKLKB1
SCHEMBL4433285 0.93 PLG (0.39) F2PLGF10PLAUKLKB1
SCHEMBL4432506 0.90 PLG (0.36) F2PLGF10PLAUKLKB1
SCHEMBL4428156 0.90 PLG (0.39) F2PLGF10PLAUKLKB1
SCHEMBL4436533 0.90 PLG (0.39) F2PLGF10PLAUKLKB1
SCHEMBL4428164 0.90 PLG (0.39) F2PLGF10PLAUKLKB1
SCHEMBL4431591 0.90 PLG (0.35) F2PLGF10PLAUKLKB1
SCHEMBL4438792 0.89 PLG (0.39) F2PLGF10PLAUKLKB1
SCHEMBL4433216 0.89 PLG (0.35) F2PLGF10PLAUKLKB1
SCHEMBL4432533 0.89 PLG (0.39) F2PLGF10PLAUKLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2125739-A1 MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF ENCYSIVE PHARMACEUTICALS, INC. (US) 2009-12-02 — — EP disclosed
WO-2008079371-A1 MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF ENCYSIVE PHARMACEUTICALS, INC. (US) 2008-07-03 — — WO disclosed