Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 6/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950114 | 0.81 | TDP1 (0.41) | TDP1MEN1KMT2ATSHRMAPK1 | |
| SCHEMBL25009711 | 0.78 | TDP1 (0.39) | TDP1MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL30687346 | 0.76 | TDP1 (0.44) | TDP1MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL18528244 | 0.75 | TDP1 (0.41) | TDP1MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL1665727 | 0.70 | MEN1 (0.41) | TDP1MEN1KMT2ATSHRMAPK1 | |
| SCHEMBL10864074 | 0.70 | TDP1 (0.40) | TDP1MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL29234900 | 0.67 | TDP1 (0.56) | TDP1MEN1KMT2ATSHRMAPK1 | |
| SCHEMBL12359993 | 0.66 | CA4 (0.43) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| SCHEMBL11580065 | 0.66 | CA4 (0.43) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| SCHEMBL22797268 | 0.66 | TDP1 (0.35) | TDP1MEN1KMT2AHRH3PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137193-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | Sanofi-Aventis (FR) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008112483-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2008-09-18 | — | — | WO | disclosed |