Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3597437 | 0.85 | BRD4 (0.50) | BRD4KDM4EHSD17B10L3MBTL1MAPT | |
| SCHEMBL689067 | 0.73 | BRD4 (0.45) | BRD4PTK2KDM4EHSD17B10MAPT | |
| SCHEMBL3592938 | 0.72 | BRD4 (0.60) | BRD4KDM4EHSD17B10L3MBTL1MAPT | |
| SCHEMBL31696410 | 0.70 | KDM4E (0.42) | BRD4PTK2KDM4EHSD17B10L3MBTL1 | |
| SCHEMBL688491 | 0.65 | BRD4 (0.58) | BRD4KDM4EHSD17B10L3MBTL1MAPT | |
| SCHEMBL13983006 | 0.64 | ALDH1A1 (0.63) | L3MBTL1SMN1; SMN2KMT2AALDH1A1TSHR | |
| SCHEMBL23649464 | 0.63 | CCNB2 (0.39) | BRD4KDM4EL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL5253717 | 0.63 | KDM4E (0.39) | BRD4PTK2KDM4EHSD17B10L3MBTL1 | |
| SCHEMBL6580237 | 0.62 | GRM6 (0.40) | HSD17B10ALDH1A1TSHRLMNAADORA1 | |
| SCHEMBL30580683 | 0.62 | KDM4E (0.54) | KDM4EHSD17B10MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118102-A1 | TRICYCLIC INDOLES AND (4,5-DIHYDRO) INDOLES | Nerviano Medical Sciences S.r.l. (IT) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008065054-A1 | TRICYCLIC INDOLES AND (4,5-DIHYDRO) INDOLES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2008-06-05 | — | — | WO | disclosed |