Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL63851 | 0.85 | TLR7 (0.39) | KMT2AMEN1TLR7POLBALDH1A1 | |
| SCHEMBL63220 | 0.80 | NR3C2 (0.47) | KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL4429135 | 0.79 | CYP19A1 (0.44) | KMT2AMEN1POLBALDH1A1HPGD | |
| SCHEMBL64487 | 0.72 | ADRA1A (0.43) | KMT2AMEN1POLBALDH1A1HTT | |
| SCHEMBL25648716 | 0.70 | POLB (0.71) | KMT2AMEN1POLBALDH1A1HPGD | |
| SCHEMBL64323 | 0.69 | KMT2A (0.49) | KMT2AMEN1TLR7ALDH1A1HPGD | |
| SCHEMBL24483184 | 0.69 | KMT2A (0.62) | KMT2AMEN1POLBALDH1A1HPGD | |
| SCHEMBL16678807 | 0.68 | MEN1 (0.43) | KMT2AMEN1TLR7POLBALDH1A1 | |
| SCHEMBL23827458 | 0.68 | HTT (0.48) | KMT2AMEN1TLR7POLBALDH1A1 | |
| SCHEMBL4664847 | 0.67 | HSD17B10 (0.65) | KMT2AMEN1POLBHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |