Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MYC | P01106 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18367783 | 0.87 | TP53 (0.56) | NPC1TP53MYCKMT2AALDH1A1 | |
| SCHEMBL13995836 | 0.83 | NPC1 (0.68) | NPC1KMT2AJAK2JAK1ALDH1A1 | |
| SCHEMBL24040867 | 0.81 | NPC1 (0.63) | NPC1TP53KMT2AJAK2JAK1 | |
| SCHEMBL4925703 | 0.81 | NPC1 (0.58) | NPC1MYCKMT2AJAK2JAK1 | |
| SCHEMBL30444401 | 0.80 | NPC1 (0.57) | NPC1KMT2AJAK2JAK1ALDH1A1 | |
| SCHEMBL3328193 | 0.80 | NPC1 (0.57) | NPC1KMT2AJAK2JAK1ALDH1A1 | |
| SCHEMBL7468796 | 0.79 | MYC (0.53) | MYCKMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL22717843 | 0.78 | TP53 (0.52) | NPC1TP53ALDH1A1KDM4EHPGD | |
| SCHEMBL11400762 | 0.78 | MYC (0.58) | MYCKMT2AALDH1A1KDM4EMAPT | |
| Dimethyl Phthalate SCHEMBL29215693 | 0.77 | ALDH1A1 (0.49) | NPC1TP53MYCKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |