Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433606 | 0.84 | MAPT (0.33) | MAPTTSHR | |
| SCHEMBL64313 | 0.81 | NPC1 (0.53) | MAPTHTTKDM4ETP53NPC1 | |
| SCHEMBL64802 | 0.81 | NFKB1 (0.40) | MAPTHTTLMNAKDM4ETP53 | |
| SCHEMBL63752 | 0.73 | TNIK (0.40) | KDM4ETP53NPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL63566 | 0.73 | TNIK (0.39) | KDM4ETP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL65041 | 0.73 | NPC1 (0.55) | MAPTTSHRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL64247 | 0.72 | FGFR1 (0.47) | TP53RAB9A | |
| SCHEMBL63258 | 0.72 | FGFR1 (0.51) | MAPTTSHRHTTLMNAKDM4E | |
| SCHEMBL63320 | 0.72 | FGFR1 (0.48) | MAPTNPC1RAB9AKMT2AFLT3 | |
| SCHEMBL63691 | 0.71 | FGFR1 (0.47) | FGFR4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |