Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 14/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 12/20 | 0.41 |
| ▸ | PGR | P06401 | 9/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440757 | 0.91 | NR3C1 (0.39) | NR3C1NR3C2PGRCYP1A2CYP3A4 | |
| SCHEMBL4439342 | 0.91 | NR3C1 (0.39) | NR3C1NR3C2PGRCYP1A2CYP3A4 | |
| SCHEMBL4436562 | 0.89 | NR3C1 (0.39) | NR3C1NR3C2PGRCYP1A2CYP3A4 | |
| SCHEMBL4437187 | 0.86 | MEN1 (0.40) | NR3C1NR3C2PGRCYP1A2CYP3A4 | |
| SCHEMBL4442284 | 0.84 | MEN1 (0.40) | NR3C1NR3C2PGRCYP1A2CYP3A4 | |
| SCHEMBL4439311 | 0.84 | NR3C1 (0.43) | NR3C1NR3C2PGRCYP1A2CYP3A4 | |
| SCHEMBL4438774 | 0.83 | NR3C1 (0.52) | NR3C1NR3C2PGRCYP1A2CYP3A4 | |
| SCHEMBL4439332 | 0.83 | NR3C1 (0.43) | NR3C1NR3C2PGRCYP1A2CYP3A4 | |
| SCHEMBL4441125 | 0.82 | NR3C2 (0.44) | NR3C1NR3C2PGRCYP1A2CYP3A4 | |
| SCHEMBL4438023 | 0.82 | NR3C1 (0.38) | NR3C1NR3C2PGRCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136811-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008124745-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-10-16 | — | — | WO | disclosed |