Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11312407 | 0.98 | POLB (0.49) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL27252294 | 0.94 | POLB (0.49) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL1569974 | 0.86 | NPC1 (0.52) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL9808095 | 0.86 | NPC1 (0.55) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL5172043 | 0.86 | POLB (0.56) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL5169781 | 0.84 | POLB (0.54) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL28435021 | 0.84 | POLB (0.54) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL20040862 | 0.83 | NPC1 (0.48) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL5168911 | 0.81 | NPC1 (0.65) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL424971 | 0.80 | HPGD (0.56) | NPC1RAB9APOLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136811-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008124745-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-10-16 | — | — | WO | disclosed |
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |
| US-4308283-A | FUNGICIDES, BACTERICIDES | INTERNATIONAL MINERALS & CHEMICAL CORP. (US) | 1981-12-29 | — | — | US | disclosed |
| US-4260634-A | PHENYLTHIOALKYLAMIDES, BACTERICIDES, FUNGICIDES | INTERNATIONAL MINERALS & CHEMICAL CORP. (US) | 1981-04-07 | — | — | US | disclosed |