Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.37 |
| ▸ | PGR | P06401 | 3/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436592 | 0.82 | NR3C1 (0.41) | KMT2ASMN1; SMN2MEN1LMNATSHR | |
| SCHEMBL4440638 | 0.81 | NR3C1 (0.41) | ALDH1A1KMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL3228288 | 0.78 | NR3C1 (0.60) | ALDH1A1KMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL4439493 | 0.78 | NR3C1 (0.43) | KMT2AMEN1TSHRL3MBTL1NR3C1 | |
| SCHEMBL4445154 | 0.78 | NR3C1 (0.43) | KMT2ASMN1; SMN2MEN1LMNATSHR | |
| SCHEMBL4437844 | 0.78 | NR3C1 (0.43) | KMT2ASMN1; SMN2MEN1LMNATSHR | |
| SCHEMBL4439498 | 0.77 | NR3C1 (0.44) | KMT2ASMN1; SMN2MEN1LMNATSHR | |
| SCHEMBL4444804 | 0.77 | NR3C1 (0.38) | KMT2AMEN1TSHRHTTNR3C1 | |
| SCHEMBL4442292 | 0.77 | NR3C1 (0.38) | KMT2AMEN1TSHRNR3C1PGR | |
| SCHEMBL4435000 | 0.76 | NR3C1 (0.38) | ALDH1A1KMT2AMEN1TSHRNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136811-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008124745-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-10-16 | — | — | WO | disclosed |