Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15169337 | 0.88 | SMO (1.00) | SMO | |
| SCHEMBL15169592 | 0.84 | SMO (1.00) | SMO | |
| SCHEMBL4440843 | 0.77 | SMO (1.00) | SMO | |
| SCHEMBL2714431 | 0.75 | SMO (1.00) | SMO | |
| SCHEMBL2713607 | 0.72 | SMO (1.00) | SMO | |
| SCHEMBL17411275 | 0.70 | SMO (0.62) | SMO | |
| SCHEMBL2713162 | 0.69 | SMO (1.00) | SMO | |
| SCHEMBL15169663 | 0.69 | SMO (1.00) | SMO | |
| SCHEMBL4437106 | 0.69 | SMO (0.57) | SMO | |
| SCHEMBL31722781 | 0.68 | OPRK1 (0.67) | SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630134-B9 | PYRIDINE-2- DERIVATIVES AS SMOOTHENED RECEPTOR MODULATORS | PFIZER (US) | 2018-04-18 | — | — | EP | disclosed |
| US-9056865-B2 | Pyridine-2-derivatives as smoothened receptor modulators | PFIZER INC. (US) | 2015-06-16 | — | — | US | disclosed |
| US-9056865-B2 | Pyridine-2-derivatives as smoothened receptor modulators | PFIZER INC. (US) | 2015-06-16 | — | — | US | disclosed |
| US-9056865-B2 | Pyridine-2-derivatives as smoothened receptor modulators | PFIZER INC. (US) | 2015-06-16 | — | — | US | disclosed |
| EP-2630134-B1 | PYRIDINE-2- DERIVATIVES AS SMOOTHENED RECEPTOR MODULATORS | PFIZER (US) | 2015-05-20 | — | — | EP | disclosed |
| US-20130210800-A1 | PYRIDINE-2-DERIVATIVES AS SMOOTHENED RECEPTOR MODULATORS | PFIZER INC. (US) | 2013-08-15 | — | — | US | disclosed |
| US-20130210800-A1 | PYRIDINE-2-DERIVATIVES AS SMOOTHENED RECEPTOR MODULATORS | PFIZER INC. (US) | 2013-08-15 | — | — | US | disclosed |
| US-20130210800-A1 | PYRIDINE-2-DERIVATIVES AS SMOOTHENED RECEPTOR MODULATORS | PFIZER INC. (US) | 2013-08-15 | — | — | US | disclosed |
| WO-2012052948-A1 | PYRIDINE- 2- DERIVATIVES AS SMOOTHENED RECEPTOR MODULATORS | PFIZER INC. (US) | 2012-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130210800-A1 | PYRIDINE-2-DERIVATIVES AS SMOOTHENED RECEPTOR MODULATORS | SMO, EDNRB, RXFP1 | SMO 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.