Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | CASP1 | P29466 | 3/20 | 0.50 |
| ▸ | CASP7 | P55210 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | EDNRA | P25101 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4449108 | 0.83 | EDNRA (0.52) | ALDH1A1LMNAMAPK1NPSR1MAPT | |
| SCHEMBL29900505 | 0.80 | EDNRA (0.55) | ALDH1A1MAPK1TSHRHPGDKDM4E | |
| SCHEMBL23092875 | 0.80 | EDNRA (0.55) | ALDH1A1MAPK1TSHRHPGDKDM4E | |
| SCHEMBL4443344 | 0.79 | LMNA (0.55) | LMNATSHRSMN1; SMN2EDNRA | |
| SCHEMBL4450789 | 0.79 | EDNRA (0.49) | EDNRAKMT2A | |
| SCHEMBL4446573 | 0.78 | NSD2 (0.63) | ALDH1A1LMNAMAPK1NPSR1POLB | |
| SCHEMBL4446944 | 0.78 | NSD2 (0.64) | ALDH1A1LMNAHPGDKDM4EEDNRA | |
| SCHEMBL4448161 | 0.78 | NPY5R (0.50) | POLBEDNRAKMT2AMEN1 | |
| SCHEMBL4448416 | 0.78 | NSD2 (0.54) | EDNRA | |
| SCHEMBL4449304 | 0.78 | CCR8 (0.53) | ALDH1A1POLBHPGDKDM4EEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547716-B2 | Sulfonamide derivatives | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2009-06-16 | — | — | US | disclosed |
| US-7531334-B2 | Polymeric microcarriers for cell culture functions | XEROX CORPORATION (US) | 2009-05-12 | — | — | US | disclosed |
| EP-1402890-B1 | SULFONAMIDE DERIVATIVES | INST MED MOLECULAR DESIGN INC (JP) | 2008-01-09 | — | — | EP | disclosed |
| US-20070243607-A1 | POLYMERIC MICROCARRIERS FOR CELL CULTURE FUNCTIONS | XEROX CORPORATION (US) | 2007-10-18 | — | — | US | disclosed |
| US-7276254-B2 | Emulsion/aggregation polymeric microspheres for biomedical applications and methods of making same | XEROX CORPORATION (US) | 2007-10-02 | — | — | US | disclosed |
| US-20040234622-A1 | Sulfonamide derivatives | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2004-11-25 | — | — | US | disclosed |
| EP-1402890-A1 | SULFONAMIDE DERIVATIVES | Institute of Medicinal Molecular Design, Inc. (JP) | 2004-03-31 | — | — | EP | disclosed |
| US-20030211035-A1 | Emulsion/aggregation polymeric microspheres for biomedical applications and methods of making same | XEROX CORPORATION | 2003-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040234622-A1 | Sulfonamide derivatives | PCNA, TOP2A, DDB1 | ALDH1A1 980/4885LMNA 1312/4885MAPK1 1231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.