Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432954 | 0.85 | PIK3CD (0.38) | PIK3CDPIK3CGPIK3CAPIK3CBMAPK1 | |
| SCHEMBL15320238 | 0.83 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL17240937 | 0.81 | PIK3CG (0.52) | PIK3CDPIK3CGPIK3CAPIK3CBMAPK1 | |
| SCHEMBL4184951 | 0.81 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL27781233 | 0.81 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| Water SCHEMBL17240976 | 0.80 | PIK3CG (0.51) | PIK3CDPIK3CGPIK3CAPIK3CBMAPK1 | |
| SCHEMBL4435013 | 0.80 | PIK3CD (0.37) | PIK3CDPIK3CGPIK3CAPIK3CBMAPK1 | |
| SCHEMBL4442948 | 0.78 | PIK3CG (0.43) | PIK3CDPIK3CGPIK3CAPIK3CBMAPK1 | |
| SCHEMBL248986 | 0.78 | PIK3CD (0.40) | PIK3CDPIK3CGPIK3CAPIK3CBMAPK1 | |
| SCHEMBL249625 | 0.77 | PIK3CD (0.35) | PIK3CDPIK3CGPIK3CAPIK3CBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |