Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 3/20 | 0.43 |
| ▸ | GBA1 | P04062 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17240937 | 0.84 | PIK3CG (0.52) | PIK3CGALDH1A1LMNAMAPK1PIK3CD | |
| Water SCHEMBL17240976 | 0.83 | PIK3CG (0.51) | PIK3CGALDH1A1LMNAMAPK1PIK3CD | |
| SCHEMBL4432954 | 0.81 | PIK3CD (0.38) | PIK3CGCLK4CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4435013 | 0.81 | PIK3CD (0.37) | PIK3CGCLK4CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27781196 | 0.79 | PIK3CD (0.55) | PIK3CGMEN1KMT2APIK3CDPIK3CA | |
| SCHEMBL4178387 | 0.79 | PIK3CD (0.55) | PIK3CGMEN1KMT2APIK3CDPIK3CA | |
| SCHEMBL248986 | 0.79 | PIK3CD (0.40) | PIK3CGCLK4ALDH1A1MEN1LMNA | |
| SCHEMBL18798891 | 0.78 | PIK3CG (0.50) | PIK3CGLMNAMAPK1PIK3CDPIK3CA | |
| SCHEMBL249677 | 0.78 | PIK3CD (0.36) | PIK3CGCLK4ALDH1A1MEN1LMNA | |
| SCHEMBL4442917 | 0.78 | PIK3CD (0.42) | PIK3CGLMNAMAPK1PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |