Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.38 |
| ▸ | SCD | O00767 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4443105 | 0.99 | KDM4E (0.40) | KDM4ESLC6A9MAPTSMN1; SMN2POLB | |
| SCHEMBL4444286 | 0.89 | CCR1 (0.38) | KDM4EMAPTSMN1; SMN2LMNATP53 | |
| SCHEMBL2955406 | 0.85 | CKS1B (0.44) | KMT2AMEN1 | |
| SCHEMBL2961821 | 0.84 | CKS1B (0.44) | — | |
| SCHEMBL2957583 | 0.80 | HTR7 (0.48) | MAPK11MAPK14CSNK1D | |
| SCHEMBL2955161 | 0.79 | HTR7 (0.47) | MAPK11MAPK14CSNK1D | |
| SCHEMBL4435035 | 0.77 | IDO1 (0.41) | KDM4EMAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL2958371 | 0.77 | CKS1B (0.55) | MAPTALDH1A1MET | |
| SCHEMBL2966669 | 0.75 | RET (0.44) | MAPTLMNAALDH1A1 | |
| SCHEMBL27786505 | 0.73 | CSNK1D (0.40) | KDM4ELMNATP53MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121630-A1 | FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008098892-A1 | FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-21 | — | — | WO | disclosed |