Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TDP2 | O95551 | 2/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4229154 | 0.89 | POLB (0.46) | POLBTSHRTDP2NEK2RAB9A | |
| SCHEMBL953438 | 0.86 | POLB (0.69) | POLBTSHRTDP2NEK2RAB9A | |
| SCHEMBL950042 | 0.85 | POLB (0.71) | POLBTSHRTDP2NEK2RAB9A | |
| SCHEMBL950407 | 0.83 | TDP2 (0.39) | POLBTSHRTDP2NEK2KIF11 | |
| SCHEMBL951763 | 0.71 | POLB (0.46) | POLBTSHRTDP2NEK2RAB9A | |
| SCHEMBL4599178 | 0.71 | POLB (0.46) | POLBTSHRTDP2NEK2RAB9A | |
| SCHEMBL950279 | 0.69 | POLB (0.64) | POLBTSHRNEK2RAB9AKMT2A | |
| SCHEMBL15943169 | 0.69 | NEK2 (0.51) | POLBTSHRNEK2 | |
| SCHEMBL15943284 | 0.69 | POLB (0.49) | POLBTSHRNEK2 | |
| SCHEMBL951124 | 0.67 | TSHR (0.72) | POLBTSHRNEK2RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121625-A1 | GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS | Glaxo Group Limited (GB) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008092879-A1 | GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2008-08-07 | — | — | WO | disclosed |