SCHEMBL4443642

SCHEMBL4443642

CC[C@H](C)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 4/20 0.61
TRPA1 O75762 4/20 0.57
LMNA P02545 1/20 0.54
AOC3 Q16853 2/20 0.54
RIPK1 Q13546 1/20 0.52
TSHR P16473 2/20 0.50
SLC7A5 Q01650 1/20 0.49
HDAC4 P56524 1/20 0.48
HDAC2 Q92769 1/20 0.48
HDAC8 Q9BY41 1/20 0.48
ALDH1A1 P00352 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17453236 1.00 TAAR1 (0.61) TAAR1TRPA1LMNAAOC3RIPK1
SCHEMBL136376 1.00 TAAR1 (0.61) TAAR1TRPA1LMNAAOC3RIPK1
Benzene SCHEMBL5290987 1.00 TAAR1 (0.61) TAAR1TRPA1LMNAAOC3RIPK1
SCHEMBL31498533 0.97 TAAR1 (0.58) TAAR1TRPA1LMNAAOC3RIPK1
Hydrogen Peroxide SCHEMBL190109 0.97 TRPA1 (0.61) TAAR1TRPA1LMNAAOC3RIPK1
Hydrogen Peroxide SCHEMBL27735407 0.97 TRPA1 (0.61) TAAR1TRPA1LMNAAOC3RIPK1
Ammonia Solution, Strong SCHEMBL6014467 0.97 TAAR1 (0.58) TAAR1TRPA1LMNAAOC3RIPK1
Hydrogen Peroxide SCHEMBL11692595 0.97 TRPA1 (0.61) TAAR1TRPA1LMNAAOC3RIPK1
Methane SCHEMBL28848997 0.97 TAAR1 (0.58) TAAR1TRPA1LMNAAOC3RIPK1
SCHEMBL27361065 0.97 TAAR1 (0.58) TAAR1TRPA1LMNAAOC3RIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2900223-B1 NOVEL COMPOUNDS THAT ARE ERK INHIBITORS MERCK SHARP & DOHME (US) 2017-10-25 EP disclosed
US-9770439-B2 Hepatitis C virus inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2017-09-26 US disclosed
US-20130196189-A1 NONAQUEOUS ELECTROLYTE SECONDARY BATTERY, METHOD FOR MANUFACTURING NONAQUEOUS ELECTROLYTE SECONDARY BATTERY, AND VEHICLE COMPRISING NONAQUEOUS ELECTROLYTE SECONDARY BATTERY TOYOTA JIDOSHA KABUSHIKI KAISHA (JP) 2013-08-01 US disclosed
EP-2114906-A1 NOVEL 2-AMINOOXAZOLINES AS TAAR1 LIGANDS FOR CNS DISORDERS F. Hoffmann-Roche AG (CH) 2009-11-11 EP disclosed
WO-2008092785-A1 NOVEL 2-AMINOOXAZOLINES AS TAAR1 LIGANDS FOR CNS DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2008-08-07 WO disclosed