SCHEMBL4444047

SCHEMBL4444047

CC(C)(C)[Si](C)(C)OC1CCNCC1NC(=O)O

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SSTR4 P31391 10/20 0.35
SSTR1 P30872 6/20 0.35
PPM1D O15297 1/20 0.32
ATR Q13535 1/20 0.30
HTR3A P46098 1/20 0.30
HTR4 Q13639 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2691333 1.00 SSTR4 (0.35) SSTR4SSTR1PPM1DATRHTR3A
SCHEMBL2691929 1.00 SSTR4 (0.35) SSTR4SSTR1PPM1DATRHTR3A
SCHEMBL15414463 0.89 SSTR4 (0.35) SSTR4SSTR1PPM1DHTR3AHTR4
SCHEMBL3384856 0.89 SSTR4 (0.35) SSTR4SSTR1PPM1DHTR3AHTR4
SCHEMBL3384852 0.89 SSTR4 (0.35) SSTR4SSTR1PPM1DHTR3AHTR4
SCHEMBL15414462 0.89 SSTR4 (0.35) SSTR4SSTR1PPM1DHTR3AHTR4
SCHEMBL1710440 0.88 GAA (0.37) SSTR4SSTR1
SCHEMBL4126273 0.88 GAA (0.37) SSTR4SSTR1
SCHEMBL4126276 0.88 GAA (0.37) SSTR4SSTR1
SCHEMBL3877927 0.87 PPM1D (0.32) PPM1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4186897-A1 PYRIDINECARBOXAMIDE COMPOUND USEFUL AS PIM KINASE INHIBITOR Incyte Holdings Corporation (US) 2023-05-31 EP disclosed
EP-3670506-B1 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS INCYTE HOLDINGS CORP (US) 2023-01-04 EP disclosed
US-11229631-B2 Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors INCYTE CORPORATION (US) 2022-01-25 US disclosed
US-20200405702-A1 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS INCYTE CORPORATION 2020-12-31 US disclosed
US-10828290-B2 Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors INCYTE CORPORATION (US) 2020-11-10 US disclosed
EP-3670506-A1 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS Incyte Holdings Corporation (US) 2020-06-24 EP disclosed
US-20200155527-A1 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS INCYTE HOLDINGS CORPORATION 2020-05-21 US disclosed
EP-2945939-B1 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS INCYTE HOLDINGS CORP (US) 2020-03-04 EP disclosed
US-20190209537-A1 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS INCYTE CORPORATION 2019-07-11 US disclosed
US-10265307-B2 Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors INCYTE CORPORATION (US) 2019-04-23 US disclosed
EP-2945939-A1 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS Incyte Corporation (US) 2015-11-25 EP disclosed
US-20150329534-A1 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS INCYTE CORPORATION 2015-11-19 US disclosed
US-20140249135-A1 PIM KINASE INHIBITORS AND METHODS OF THEIR USE NOVARTIS AG (CH) 2014-09-04 US disclosed
US-8822497-B2 PIM kinase inhibitors and methods of their use NOVARTIS AG (CH) 2014-09-02 US disclosed
WO-2014113388-A1 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS INCYTE CORPORATION (US) 2014-07-24 WO disclosed
US-20140200227-A1 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS INCYTE CORPORATION (US) 2014-07-17 US disclosed
EP-2132177-B1 PIM KINASE INHIBITORS AND METHODS OF THEIR USE NOVARTIS AG (CH) 2013-07-17 EP disclosed
US-20120208815-A1 PIM KINASE INHIBITORS AND METHODS OF THEIR USE NOVARTIS AG (CH) 2012-08-16 US disclosed
EP-2132177-A1 PIM KINASE INHIBITORS AND METHODS OF THEIR USE Novartis Ag (CH) 2009-12-16 EP disclosed
WO-2008106692-A1 PIM KINASE INHIBITORS AND METHODS OF THEIR USE NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2008-09-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190209537-A1 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS PIM2, PIM1, PIM3 SSTR4 3877/4885SSTR1 4510/4885PPM1D 652/4885
US-10265307-B2 Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors PIM2, PIM1, PIM3 SSTR4 3877/4885SSTR1 4510/4885PPM1D 652/4885
US-20140249135-A1 PIM KINASE INHIBITORS AND METHODS OF THEIR USE PIM1, PIM2, PIM3 SSTR4 3180/4885SSTR1 3256/4885PPM1D 414/4885
US-20150329534-A1 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS PIM2, PIM1, PIM3 SSTR4 3877/4885SSTR1 4510/4885PPM1D 652/4885
US-20200405702-A1 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS PIM2, PIM1, PIM3 SSTR4 3877/4885SSTR1 4510/4885PPM1D 652/4885
US-20200155527-A1 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS PIM2, PIM1, PIM3 SSTR4 3877/4885SSTR1 4510/4885PPM1D 652/4885
US-11229631-B2 Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors PIM2, PIM1, PIM3 SSTR4 3877/4885SSTR1 4510/4885PPM1D 652/4885
US-20120208815-A1 PIM KINASE INHIBITORS AND METHODS OF THEIR USE PIM1, PIM2, PIM3 SSTR4 3180/4885SSTR1 3256/4885PPM1D 414/4885
US-10828290-B2 Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors PIM2, PIM1, PIM3 SSTR4 3877/4885SSTR1 4510/4885PPM1D 652/4885
US-20140200227-A1 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS PIM2, PIM1, PIM3 SSTR4 3877/4885SSTR1 4510/4885PPM1D 652/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.