Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 20/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 15/20 | 0.67 |
| ▸ | CTSS | P25774 | 5/20 | 0.64 |
| ▸ | CTSB | P07858 | 4/20 | 0.62 |
| ▸ | CTSL | P07711 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4453995 | 0.87 | CTSK (0.51) | CTSKKCNH2CTSSCTSBCTSL | |
| SCHEMBL13707274 | 0.87 | CTSK (0.60) | CTSKKCNH2CTSS | |
| SCHEMBL4448454 | 0.87 | CTSK (0.59) | CTSKKCNH2CTSSCTSBCTSL | |
| SCHEMBL8277368 | 0.86 | CTSK (0.76) | CTSKKCNH2CTSSCTSBCTSL | |
| SCHEMBL4440683 | 0.82 | CTSK (0.48) | CTSKKCNH2CTSSCTSBCTSL | |
| SCHEMBL4444062 | 0.81 | CTSK (0.49) | CTSKKCNH2CTSSCTSBCTSL | |
| SCHEMBL4444381 | 0.81 | CTSK (1.00) | CTSKKCNH2CTSSCTSBCTSL | |
| SCHEMBL4453804 | 0.81 | CTSK (0.77) | CTSKKCNH2CTSSCTSBCTSL | |
| SCHEMBL4448235 | 0.80 | CTSK (0.65) | CTSKKCNH2CTSSCTSBCTSL | |
| SCHEMBL3873029 | 0.80 | CTSK (0.57) | CTSKKCNH2CTSSCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589095-B2 | 4-phenyl-pyrimidine-2-carbonitrile derivatives | N.V. ORGANON (NL) | 2009-09-15 | — | — | US | disclosed |
| US-7589095-B2 | 4-phenyl-pyrimidine-2-carbonitrile derivatives | N.V. ORGANON (NL) | 2009-09-15 | — | — | US | disclosed |
| EP-1758870-B1 | 4-PHENYL-PYRIMIDINE-2-CARBONITRILE DERIVATIVES | ORGANON NV (NL) | 2008-08-13 | — | — | EP | disclosed |
| US-20080090813-A1 | 4-Phenyl-Pyrimidine-2-Carbonitrile Derivatives | Cai, Jiaqiang | 2008-04-17 | — | — | US | disclosed |
| US-20080090813-A1 | 4-Phenyl-Pyrimidine-2-Carbonitrile Derivatives | Cai, Jiaqiang | 2008-04-17 | — | — | US | disclosed |
| EP-1758870-A1 | 4-PHENYL-PYRIMIDINE-2-CARBONITRILE DERIVATIVES | N.V. Organon (NL) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005121106-A1 | 4-PHENYL-PYRIMIDINE-2-CARBONITRILE DERIVATIVES | N.V. ORGANON (NL) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090813-A1 | 4-Phenyl-Pyrimidine-2-Carbonitrile Derivatives | P2RY4, P2RX4, P2RY1 | CTSK 1852/4885KCNH2 2293/4885CTSS 2645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.