Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 7/20 | 0.85 |
| ▸ | RAD52 | P43351 | 4/20 | 0.85 |
| ▸ | KIF11 | P52732 | 2/20 | 0.85 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | DRD2 | P14416 | 5/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.60 |
| ▸ | HTR2A | P28223 | 4/20 | 0.60 |
| ▸ | HTR2C | P28335 | 4/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.60 |
| ▸ | HRH1 | P35367 | 4/20 | 0.60 |
| ▸ | DRD3 | P35462 | 4/20 | 0.60 |
| ▸ | HTR2B | P41595 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11244507 | 1.00 | CYP2D6 (0.85) | CYP2D6RAD52KIF11MAPTDRD2 | |
| SCHEMBL11246700 | 0.85 | CYP2D6 (0.67) | CYP2D6RAD52KIF11MAPTDRD2 | |
| SCHEMBL11237819 | 0.82 | CYP2D6 (0.63) | CYP2D6RAD52KIF11MAPTDRD2 | |
| SCHEMBL11244510 | 0.81 | RAD52 (0.66) | CYP2D6RAD52KIF11MAPTDRD2 | |
| SCHEMBL11237816 | 0.78 | CYP2D6 (0.61) | CYP2D6RAD52KIF11MAPTDRD2 | |
| SCHEMBL11244145 | 0.77 | CYP2D6 (0.57) | CYP2D6RAD52KIF11MAPTDRD2 | |
| SCHEMBL29724166 | 0.76 | CYP2D6 (0.71) | CYP2D6RAD52MAPTDRD2CYP2C19 | |
| SCHEMBL8053156 | 0.76 | CYP2D6 (0.71) | CYP2D6RAD52MAPTDRD2CYP2C19 | |
| SCHEMBL20412086 | 0.75 | CYP2D6 (0.69) | CYP2D6RAD52MAPTDRD2CYP2C19 | |
| SCHEMBL31673776 | 0.75 | CYP2D6 (0.69) | CYP2D6RAD52MAPTDRD2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193238-B2 | Inhibition of microtubule protrusion in cancer cells | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2012-06-05 | — | — | US | disclosed |
| US-20090137473-A1 | INHIBITION OF MICROTUBULE PROTRUSION IN CANCER CELLS | UNIVERSITY OF MARYLAND, BALTIMORE | 2009-05-28 | — | — | US | disclosed |
| US-4366154-A | TRANQUILIZERS; PSYCHOLOGICAL DISORDERS | SANDOZ, INC. (US) | 1982-12-28 | — | — | US | disclosed |