Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD2 | O14939 | 16/20 | 0.43 |
| ▸ | PLD1 | Q13393 | 16/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | YEATS4 | O95619 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434535 | 0.89 | PLD2 (0.45) | PLD2PLD1OPRM1DRD2YEATS4 | |
| SCHEMBL4435629 | 0.88 | PLD2 (0.44) | PLD2PLD1OPRM1DRD2YEATS4 | |
| SCHEMBL4432988 | 0.88 | PLD2 (0.44) | PLD2PLD1OPRM1DRD2YEATS4 | |
| SCHEMBL4434580 | 0.87 | PLD2 (0.47) | PLD2PLD1OPRM1DRD2KCNH2 | |
| SCHEMBL4438902 | 0.86 | PLD2 (0.42) | PLD2PLD1OPRM1DRD2 | |
| SCHEMBL4436952 | 0.86 | PLD2 (0.43) | PLD2PLD1OPRM1DRD2 | |
| SCHEMBL5006602 | 0.86 | PLD2 (0.43) | PLD2PLD1OPRM1DRD2 | |
| SCHEMBL4435839 | 0.84 | PLD2 (0.42) | PLD2PLD1OPRM1DRD2YEATS4 | |
| SCHEMBL5000823 | 0.84 | PLD2 (0.42) | PLD2PLD1OPRM1DRD2YEATS4 | |
| SCHEMBL4435765 | 0.84 | PLD2 (0.42) | PLD2PLD1OPRM1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | claimed |
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | disclosed |