Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4006904 | 0.89 | HSD11B1 (0.61) | GRM5MMP2MMP13MCHR1KMT2A | |
| SCHEMBL4006910 | 0.89 | HSD11B1 (0.61) | GRM5MMP2MMP13MCHR1KMT2A | |
| SCHEMBL4013556 | 0.80 | HSD11B1 (0.59) | MMP2MMP13MCHR1KMT2ALMNA | |
| SCHEMBL4013552 | 0.80 | HSD11B1 (0.59) | MMP2MMP13MCHR1KMT2ALMNA | |
| SCHEMBL4002244 | 0.80 | HSD11B1 (0.63) | GRM5MMP2MMP13KMT2ALMNA | |
| SCHEMBL4002241 | 0.80 | HSD11B1 (0.63) | GRM5MMP2MMP13KMT2ALMNA | |
| SCHEMBL4006086 | 0.78 | HSD11B1 (0.63) | GRM5KMT2ACNR2HSD11B1HTT | |
| SCHEMBL4006076 | 0.78 | HSD11B1 (0.63) | GRM5KMT2ACNR2HSD11B1HTT | |
| SCHEMBL4009206 | 0.76 | HSD11B1 (0.68) | MMP2MMP13KMT2AALDH1A1CNR2 | |
| SCHEMBL4009203 | 0.76 | HSD11B1 (0.68) | MMP2MMP13KMT2AALDH1A1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | claimed |