Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Indene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indene SCHEMBL27841815 | 0.95 | CA1 (0.52) | CA1CA2CYP2D6CYP2C19PARP1 | |
| Indene SCHEMBL27507008 | 0.95 | CA1 (0.52) | CA1CA2CYP2D6CYP2C19PARP1 | |
| Indene SCHEMBL27697733 | 0.95 | CA1 (0.52) | CA1CA2CYP2D6CYP2C19PARP1 | |
| Indene SCHEMBL30807112 | 0.95 | CA1 (0.52) | CA1CA2CYP2D6CYP2C19PARP1 | |
| Indene SCHEMBL29041620 | 0.95 | CA1 (0.52) | CA1CA2CYP2D6CYP2C19PARP1 | |
| Indene SCHEMBL8336138 | 0.95 | CA1 (0.55) | CA1CA2CYP2D6CYP2C19PARP1 | |
| Indene SCHEMBL8617 | 0.95 | — | — | |
| Indene SCHEMBL29350094 | 0.95 | — | — | |
| Indene SCHEMBL23301011 | 0.92 | CA1 (0.53) | CA1CA2CYP2D6CYP2C19PARP1 | |
| Indene SCHEMBL1054910 | 0.92 | CA1 (0.53) | CA1CA2CYP2D6CYP2C19PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2028198-A1 | Propylene polymer and composition containing the same, molded object and laminate comprising these, and processes for producing propylene polymer and composition containinig the same | Idemitsu Kosan Co., Ltd. (JP) | 2009-02-25 | — | — | EP | disclosed |
| EP-2028199-A1 | Propylene polymer and composition containing the same, molded object and laminate comprising these, and processes for producing propylene polymer and composition containinig the same | Idemitsu Kosan Co., Ltd. (JP) | 2009-02-25 | — | — | EP | disclosed |
| EP-1873172-A2 | Propylene polymer and composition containing the same, molded object and laminate comprising these, and processes for producing propylene polymer and composition containing the same | Idemitsu Kosan Co., Ltd. (JP) | 2008-01-02 | — | — | EP | disclosed |
| EP-1867662-A2 | Propylene polymer and composition containing the same, molded object and laminate comprising these, and processes for producing propylene polymer and composition containing the same | Idemitsu Kosan Co., Ltd. (JP) | 2007-12-19 | — | — | EP | disclosed |
| EP-1867663-A2 | Propylene polymer and composition containing the same, molded object and laminate comprising these, and processes for producing propylene polymer and composition containing the same | Idemitsu Kosan Co., Ltd. (JP) | 2007-12-19 | — | — | EP | disclosed |
| EP-1865005-A2 | Propylene polymer and composition containing the same, molded object and laminate comprising these, and processes for producing propylene polymer and composition containing the same | Idemitsu Kosan Co., Ltd. (JP) | 2007-12-12 | — | — | EP | disclosed |
| EP-1865006-A2 | Propylene polymer and composition containing the same, molded object and laminate comprising these, and processes for producing propylene polymer and composition containing the same | Idemitsu Kosan Co., Ltd. (JP) | 2007-12-12 | — | — | EP | disclosed |
| EP-1865007-A2 | Propylene polymer and composition containing the same, molded object and laminate comprising these, and processes for producing propylene polymer and composition containing the same | Idemitsu Kosan Co., Ltd. (JP) | 2007-12-12 | — | — | EP | disclosed |
| EP-1772467-A1 | Propylene polymer and composition containing the same, molded object and laminate comprising these, and processes for producing propylene polymer and composition containing the same | IDEMITSU KOSAN CO., LTD. (JP) | 2007-04-11 | — | — | EP | disclosed |