Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.56 |
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.56 |
| ▸ | AKR1C4 | P17516 | 3/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HMGB1 | P09429 | 3/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CXCL12 | P48061 | 2/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3490091 | 0.81 | AKR1C3 (0.60) | AKR1C3AKR1C2AKR1C1AKR1C4PTPN1 | |
| SCHEMBL19745159 | 0.78 | AKR1C3 (0.78) | AKR1C3AKR1C2AKR1C1AKR1C4PTPN1 | |
| SCHEMBL17008903 | 0.76 | KDM4E (0.47) | AKR1C3AKR1C2AKR1C1PTPN1KDM4E | |
| SCHEMBL4756950 | 0.76 | ALDH1A1 (0.41) | PTPN1HSD17B10ALDH1A1HPGDHMGB1 | |
| SCHEMBL4136744 | 0.75 | CYP3A4 (0.54) | AKR1C3AKR1C2AKR1C1AKR1C4ALDH1A1 | |
| SCHEMBL330545 | 0.72 | AKR1C3 (1.00) | AKR1C3AKR1C2AKR1C1AKR1C4PTPN1 | |
| SCHEMBL31068478 | 0.72 | AKR1C3 (0.69) | AKR1C3AKR1C2AKR1C1AKR1C4PTPN1 | |
| SCHEMBL8285504 | 0.72 | AKR1C3 (0.69) | AKR1C3AKR1C2AKR1C1AKR1C4PTPN1 | |
| SCHEMBL29387062 | 0.72 | AKR1C3 (1.00) | AKR1C3AKR1C2AKR1C1AKR1C4PTPN1 | |
| SCHEMBL23043923 | 0.72 | PTPN1 (0.42) | PTPN1HSD17B10ALDH1A1HPGDHMGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134343-A2 | PYRROLO-PYRIDINE KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008124849-A2 | PYRROLO-PYRIDINE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |