Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 20/20 | 0.66 |
| ▸ | DRD4 | P21917 | 20/20 | 0.66 |
| ▸ | DRD3 | P35462 | 20/20 | 0.66 |
| ▸ | DRD1 | P21728 | 14/20 | 0.66 |
| ▸ | HTR2A | P28223 | 14/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3612900 | 0.94 | DRD2 (0.73) | DRD2DRD4DRD3DRD1HTR2A | |
| SCHEMBL3613355 | 0.89 | DRD2 (0.70) | DRD2DRD4DRD3DRD1HTR2A | |
| SCHEMBL3613900 | 0.80 | DRD2 (1.00) | DRD2DRD4DRD3DRD1HTR2A | |
| SCHEMBL3619139 | 0.77 | DRD2 (0.93) | DRD2DRD4DRD3DRD1HTR2A | |
| SCHEMBL3611189 | 0.74 | DRD2 (0.88) | DRD2DRD4DRD3DRD1HTR2A | |
| SCHEMBL3615538 | 0.73 | DRD3 (1.00) | DRD2DRD4DRD3DRD1HTR2A | |
| SCHEMBL3618443 | 0.72 | DRD2 (1.00) | DRD2DRD4DRD3DRD1HTR2A | |
| SCHEMBL3609686 | 0.71 | DRD2 (1.00) | DRD2DRD4DRD3DRD1HTR2A | |
| SCHEMBL3611252 | 0.71 | DRD2 (0.82) | DRD2DRD4DRD3DRD1HTR2A | |
| SCHEMBL3611425 | 0.70 | DRD2 (0.93) | DRD2DRD4DRD3DRD1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137185-A2 | INDOLIZINES AND AZA-ANALOG DERIVATIVES THEREOF AS CNS ACTIVE COMPOUNDS | Gmeiner, Dr. Peter (DE) | 2009-12-30 | — | — | EP | claimed |
| WO-2008113559-A2 | INDOLIZINES AND AZA-ANALOG DERIVATIVES THEREOF AS CNS ACTIVE COMPOUNDS | SCHWARZ PHARMA AG (DE) | 2008-09-25 | — | — | WO | claimed |