Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.53 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 3/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055914 | 0.90 | ADAM17 (0.55) | ADAM17ADORA2AADORA1IGF1RTLR7 | |
| SCHEMBL6211915 | 0.84 | ADAM17 (0.53) | ADAM17IGF1RTLR7MAPTNPC1 | |
| SCHEMBL31326856 | 0.84 | TLR7 (0.50) | ADAM17ADORA2AADORA1IGF1RTLR7 | |
| SCHEMBL31326858 | 0.84 | TLR7 (0.50) | ADAM17ADORA2AADORA1IGF1RTLR7 | |
| SCHEMBL7257033 | 0.81 | ADAM17 (0.55) | ADAM17PLA2G10PLA2G2ACHEK2MAPT | |
| SCHEMBL4449639 | 0.79 | ADAM17 (0.52) | ADAM17PLA2G10PLA2G2ACHEK2TLR7 | |
| SCHEMBL6632653 | 0.79 | ADAM17 (0.47) | ADAM17ADORA2AADORA1IGF1RTLR7 | |
| SCHEMBL4053152 | 0.78 | TLR7 (0.45) | ADAM17ADORA2AADORA1IGF1RTLR7 | |
| SCHEMBL5271308 | 0.76 | NCOA1 (0.55) | ADORA2AADORA1IGF1RTLR7MAPT | |
| SCHEMBL3618520 | 0.75 | ADORA2A (0.56) | ADAM17ADORA2AADORA1IGF1RTLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397137-B1 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL MYERS SQUIBB CO (US) | 2009-10-14 | — | — | EP | disclosed |