Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | VDR | P11473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13508742 | 0.83 | NOD1 (0.62) | CYP2C9CYP2C19CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL28388694 | 0.82 | TNF (0.54) | CYP2C9CYP2C19CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL24041745 | 0.82 | CYP2C9 (0.54) | CYP2C9CYP2C19CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL4445288 | 0.82 | CYP2C9 (0.51) | CYP2C9CYP2C19CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL4056354 | 0.81 | CYP2C9 (0.52) | CYP2C9CYP2C19CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL4048200 | 0.81 | CYP2C9 (0.63) | CYP2C9CYP2C19CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL3969688 | 0.80 | TNF (0.70) | VDRMEN1KMT2ALMNAMAPT | |
| SCHEMBL28385438 | 0.80 | CFTR (0.58) | CYP2C9CYP2C19CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL13508743 | 0.79 | KMT2A (0.66) | CYP2C9CYP2C19CYP1A2CYP2D6KMT2A | |
| SCHEMBL14376771 | 0.78 | HDAC1 (0.69) | CYP2C9CYP2C19CYP1A2CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397137-B1 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL MYERS SQUIBB CO (US) | 2009-10-14 | — | — | EP | disclosed |