Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 2/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4814159 | 1.00 | HDAC4 (0.33) | HDAC4HDAC8IDH1KIF11GAA | |
| SCHEMBL4813632 | 0.87 | CREBBP (0.35) | — | |
| SCHEMBL4815232 | 0.84 | CREBBP (0.37) | GAAHPGDSMN1; SMN2 | |
| SCHEMBL4816506 | 0.84 | HPGD (0.33) | HDAC4HDAC8KIF11GAAHPGD | |
| SCHEMBL4598623 | 0.84 | HPGD (0.33) | HDAC4HDAC8KIF11GAAHPGD | |
| SCHEMBL4816048 | 0.83 | KMT2A (0.34) | GAA | |
| SCHEMBL4866034 | 0.83 | NR3C1 (0.35) | KIF11SMN1; SMN2 | |
| SCHEMBL4555043 | 0.82 | MEN1 (0.33) | GAAHPGD | |
| SCHEMBL4556462 | 0.82 | MAPT (0.36) | — | |
| SCHEMBL4445605 | 0.82 | MKNK1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125825-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079139-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |