Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 2/20 | 0.48 |
| ▸ | AKT1 | P31749 | 5/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 4/20 | 0.43 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.42 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.42 |
| ▸ | ITPR3 | Q14573 | 4/20 | 0.38 |
| ▸ | ITPR1 | Q14643 | 3/20 | 0.38 |
| ▸ | ITPR2 | Q14571 | 2/20 | 0.38 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.38 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.37 |
| ▸ | INPP5A | Q14642 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 3/20 | 0.35 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818683 | 0.91 | GPR55 (0.52) | SMPD1AKT1GPR55NR5A2NR5A1 | |
| SCHEMBL9951865 | 0.81 | LPAR1 (0.43) | — | |
| SCHEMBL5962134 | 0.81 | LPAR1 (0.43) | — | |
| SCHEMBL5011536 | 0.80 | SMPD1 (0.44) | SMPD1 | |
| SCHEMBL7807533 | 0.80 | SMPD1 (0.44) | SMPD1 | |
| SCHEMBL4752182 | 0.80 | SMPD1 (0.44) | SMPD1 | |
| SCHEMBL9951538 | 0.80 | SMPD1 (0.44) | SMPD1 | |
| SCHEMBL1700578 | 0.80 | SMPD1 (0.44) | SMPD1 | |
| SCHEMBL875712 | 0.80 | SMPD1 (0.44) | SMPD1 | |
| SCHEMBL29752854 | 0.80 | SMPD1 (0.44) | SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1755574-A4 | PTEN INHIBITORS | SEMAFORE PHARMACEUTICALS INC (US) | 2009-05-13 | — | — | EP | disclosed |
| EP-1755574-A2 | PTEN INHIBITORS | Semafore Pharmaceuticals, Inc. (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005097119-A2 | PTEN INHIBITORS | SEMAFORE PHARMACEUTICALS, INC. (US) | 2005-10-20 | — | — | WO | disclosed |