Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 13/20 | 0.49 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16722735 | 0.86 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL1287156 | 0.84 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL9682338 | 0.83 | ACHE (0.51) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL5708310 | 0.83 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL5708308 | 0.83 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL4975556 | 0.82 | ACHE (0.50) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL12070289 | 0.82 | ACHE (0.50) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL4688324 | 0.81 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL2486968 | 0.80 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL10580487 | 0.80 | ACHE (0.55) | NPC1RAB9ASMN1; SMN2LMNAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3830080-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | Merck Patent GmbH (DE) | 2021-06-09 | — | — | EP | disclosed |
| WO-2020025517-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-02-06 | — | — | WO | disclosed |
| EP-2882725-A1 | SUBSTITUTED HETERO-AZEPINONES | F. Hoffmann-La Roche AG (CH) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014023708-A1 | SUBSTITUTED HETERO-AZEPINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-13 | — | — | WO | disclosed |
| EP-2043658-A2 | ANTIVIRAL PHOSPHINATE COMPOUNDS | Gilead Sciences, Inc. (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008005565-A2 | ANTIVIRAL PHOSPHINATE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2008-01-10 | — | — | WO | disclosed |
| EP-1828151-A2 | MALONAMIDE DERIVATIVES AS INHIBITORS OF GAMMA-SECRETASE FOR THE TREATMENT OF ALZHEIMER'S DISEASE | F.HOFFMANN-LA ROCHE AG (CH) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006061136-A2 | MALONAMIDE DERIVATIVES AS INHIBITORS OF GAMMA-SECRETASE FOR THE TREATMENT OF ALZHEIMER’S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-15 | — | — | WO | disclosed |