Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | DVL1 | O14640 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4447325 | 0.89 | FFAR1 (0.44) | THRATHRBMRGPRX4FFAR1KDM4E | |
| SCHEMBL1828195 | 0.88 | MRGPRX4 (0.46) | THRATHRBMRGPRX4FFAR1KDM4E | |
| SCHEMBL4441239 | 0.86 | KDR (0.39) | MRGPRX4KDM4E | |
| SCHEMBL1825488 | 0.85 | THRA (0.52) | THRATHRBMRGPRX4FFAR1KDM4E | |
| SCHEMBL1825980 | 0.85 | KDM4E (0.46) | THRATHRBMRGPRX4KDM4EALDH1A1 | |
| SCHEMBL1824746 | 0.85 | KDM4E (0.45) | THRATHRBMRGPRX4FFAR1KDM4E | |
| SCHEMBL4437297 | 0.84 | MRGPRX4 (0.45) | THRATHRBMRGPRX4FFAR1KDM4E | |
| SCHEMBL1826571 | 0.83 | MRGPRX4 (0.46) | MRGPRX4KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1825345 | 0.83 | KDM4E (0.44) | THRATHRBMRGPRX4FFAR1KDM4E | |
| SCHEMBL1825265 | 0.83 | MRGPRX4 (0.54) | THRATHRBMRGPRX4FFAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118051-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | Chelsea Therapeutics, Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008097180-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | CHELSEA THERAPEUTICS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |