Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | PYGL | P06737 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2793251 | 0.89 | GAA (0.58) | GAAHTTKDM4EMAPTMEN1 | |
| SCHEMBL4177645 | 0.88 | HTT (0.52) | GAAHTTPYGLKDM4EMAPT | |
| SCHEMBL2726967 | 0.84 | CA12 (0.53) | GAAHSP90AA1KDM4ELMNAPOLB | |
| SCHEMBL30463099 | 0.84 | CA12 (0.53) | GAAHSP90AA1KDM4ELMNAPOLB | |
| SCHEMBL1742880 | 0.83 | GAA (0.68) | GAAHSP90AA1HTTKDM4EMAPT | |
| SCHEMBL1743592 | 0.81 | ALDH1A1 (0.51) | GAAHSP90AA1HTTKDM4EHSD17B10 | |
| SCHEMBL30912978 | 0.81 | CA12 (0.57) | GAAHTTKDM4EMAPTMEN1 | |
| SCHEMBL29046583 | 0.80 | GAA (0.63) | GAAHTTKDM4EMAPTMEN1 | |
| SCHEMBL3467699 | 0.79 | NPC1 (0.54) | GAAHTTKDM4EMAPTMEN1 | |
| SCHEMBL3461530 | 0.78 | KDM4E (0.57) | GAAHTTKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069355-A1 | NOVEL TRICYCLIC SPIROPIPERIDINE COMPOUNDS, THEIR SYNTHESIS AND THEIR USES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008010765-A1 | NOVEL TRICYCLIC SPIROPIPERIDINE COMPOUNDS, THEIR SYNTHESIS AND THEIR USES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2008-01-24 | — | — | WO | disclosed |