⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL27507825 | 0.97 | CTSL (0.35) | — | |
| SCHEMBL9523334 | 0.97 | — | — | |
| SCHEMBL8607590 | 0.84 | — | — | |
| SCHEMBL9526148 | 0.72 | — | — | |
| SCHEMBL5152342 | 0.71 | — | — | |
| SCHEMBL9136159 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL31138322 | 0.69 | — | — | |
| SCHEMBL6021878 | 0.67 | — | — | |
| SCHEMBL518260 | 0.65 | CTSL (0.42) | — | |
| SCHEMBL3544433 | 0.65 | CTSL (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105622609-B | A kind of Li Gelieting preparation method | 上海万巷制药有限公司 | 2017-08-25 | — | — | CN | claimed |
| CN-103319483-B | A kind of preparation method of important intermediate of linagliptin | 药源药物化学（上海）有限公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-104277226-A | Siloxane polymers with a central polysiloxane polymer block with organofunctional radicals each having at least two bivalent groups selected from urea and/or carbamate groups and at least one UV/Vis chromophore as radical | EVONIK INDUSTRIES AG | 2015-01-14 | — | — | CN | disclosed |
| EP-2821430-A1 | Siloxane polymers with central polysiloxane polymer block with organofunctional residues, each comprising at least two bivalent groups selected from urea and/or carbamate groups and at least one UV/Vis chromophore as residue | Evonik Industries AG (DE) | 2015-01-07 | — | — | EP | disclosed |
| US-20150004112-A1 | SILOXANE POLYMERS WITH A CENTRAL POLYSILOXANE POLYMER BLOCK WITH ORGANOFUNCTIONAL RADICALS EACH HAVING AT LEAST TWO BIVALENT GROUPS SELECTED FROM UREA AND/OR CARBAMATE GROUPS AND AT LEAST ONE UV/VIS CHROMOPHORE AS RADICAL | EVONIK INDUSTRIES AG (DE) | 2015-01-01 | — | — | US | disclosed |
| CN-101959882-B | Imidazole carbonyl compound | DAIICHI SANKYO CO LTD | 2013-09-11 | — | — | CN | disclosed |
| CN-102361557-A | Process for the preparation of alogliptin | MAPI PHARMA HK LTD | 2012-02-22 | — | — | CN | disclosed |
| CN-101663273-A | Processes for the preparation of piperidinyl-substituted urea compounds | ARETE THERAPEUTICS INC | 2010-03-03 | — | — | CN | disclosed |
| EP-2125729-A1 | PROCESSES FOR THE PREPARATION OF PIPERIDINYL-SUBSTITUTED UREA COMPOUNDS | Arete Therapeutics, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| US-20080207908-A1 | PROCESSES FOR THE PREPARATION OF PIPERIDINYL-SUBSTITUTED UREA COMPOUNDS | ARETE THERAPEUTICS, INC | 2008-08-28 | — | — | US | disclosed |
| WO-1996031501-A1 | CARBONYL-PIPERAZINYL AND PIPERIDINIL COMPOUNDS WHICH INHIBIT FARNESYL PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1996-10-10 | — | — | WO | disclosed |
| WO-1996031477-A1 | TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1996-10-10 | — | — | WO | disclosed |
| EP-0550007-A2 | Eseroline derivatives having anticholinesterase activity, a process for their preparation and pharmaceutical compositions containing them | AESCULAPIUS FARMACEUTICI S.r.l. (IT) | 1993-07-07 | — | — | EP | disclosed |
| CN-1019393-B | Substituted N-[(4-piperidingl] alkyl] bicyclic condensed oxazol and thiazolaminer | JANSSEN PHARMACEUTICA NV (BE) | 1992-12-09 | — | — | CN | disclosed |
| EP-0199400-B1 | Substituted N-[(4-piperidinyl)alkyl] bicyclic condensed ozazol- and thiazolamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-09-26 | — | — | EP | disclosed |
| US-4826848-A | Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-05-02 | — | — | US | disclosed |
| US-4749702-A | PARKINSON*S DISEASE, ENTEROKINESIA | JANSSEN PHARMACEUTICA N. V. (BE) | 1988-06-07 | — | — | US | disclosed |
| US-4689330-A | PARKINSON DISEASE | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-08-25 | — | — | US | disclosed |
| EP-0199400-A2 | Substituted N-[(4-piperidinyl)alkyl] bicyclic condensed ozazol- and thiazolamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-10-29 | — | — | EP | disclosed |
| EP-0094343-A1 | Polyalkylpiperidine derivatives containing isocyanate groups | CIBA-GEIGY AG (CH) | 1983-11-16 | — | — | EP | disclosed |