Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | CTSV | O60911 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | DVL1 | O14640 | 1/20 | 0.41 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1822935 | 0.97 | FFAR1 (0.47) | MAOBMAOAKDM4EALDH1A1MEN1 | |
| SCHEMBL1826956 | 0.94 | MAOB (0.52) | MAOBMAOAKDM4EALDH1A1MEN1 | |
| SCHEMBL1825744 | 0.93 | FFAR1 (0.49) | MAOBMAOAKDM4EALDH1A1MEN1 | |
| SCHEMBL1825736 | 0.91 | TSHR (0.49) | MAOBMAOAKDM4EALDH1A1MEN1 | |
| SCHEMBL1824518 | 0.89 | MAOB (0.49) | MAOBMAOAKDM4EALDH1A1MEN1 | |
| SCHEMBL1825523 | 0.89 | TSHR (0.49) | MAOBMAOAKDM4EALDH1A1MEN1 | |
| SCHEMBL1826202 | 0.87 | MAOB (0.53) | MAOBKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1824454 | 0.85 | MRGPRX4 (0.53) | MAOBKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1825707 | 0.84 | THRA (0.49) | MAOBKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1823119 | 0.84 | KDM4E (0.45) | MAOBMAOAKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118051-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | Chelsea Therapeutics, Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008097180-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | CHELSEA THERAPEUTICS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |