⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL101147 | 0.78 | — | — | |
| SCHEMBL384172 | 0.78 | — | — | |
| SCHEMBL477969 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL31376727 | 0.75 | — | — | |
| SCHEMBL357391 | 0.75 | — | — | |
| SCHEMBL4495282 | 0.75 | — | — | |
| SCHEMBL9968799 | 0.75 | — | — | |
| SCHEMBL477720 | 0.75 | — | — | |
| SCHEMBL23591143 | 0.74 | — | — | |
| SCHEMBL21257624 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4063858-A1 | ANTIBODY-DEPENDENT CELL-MEDIATED PHAGOCYTOSIS ASSAY FOR RELIABLY MEASURING UPTAKE OF AGGREGATED PROTEINS | Biogen International Neuroscience GmbH (CH) | 2022-09-28 | — | — | EP | claimed |
| US-11340225-B2 | Antibody-dependent cell-mediated phagocytosis assay for reliably measuring uptake of aggregated proteins | BIOGEN INTERNATIONAL NEUROSCIENCE GMBH (CH) | 2022-05-24 | — | — | US | claimed |
| EP-3430397-B1 | ANTIBODY-DEPENDENT CELL-MEDIATED PHAGOCYTOSIS ASSAY FOR RELIABLY MEASURING UPTAKE OF AGGREGATED PROTEINS | BIOGEN INT NEUROSCIENCE GMBH (CH) | 2022-02-23 | — | — | EP | claimed |
| US-20190079077-A1 | ANTIBODY-DEPENDENT CELL-MEDIATED PHAGOCYTOSIS ASSAY FOR RELIABLY MEASURING UPTAKE OF AGGREGATED PROTEINS | BIOGEN INTERNATIONAL NEUROSCIENCE GMBH (CH) | 2019-03-14 | — | — | US | claimed |
| EP-3430397-A1 | ANTIBODY-DEPENDENT CELL-MEDIATED PHAGOCYTOSIS ASSAY FOR RELIABLY MEASURING UPTAKE OF AGGREGATED PROTEINS | Biogen International Neuroscience GmbH (CH) | 2019-01-23 | — | — | EP | claimed |
| WO-2017157961-A1 | ANTIBODY-DEPENDENT CELL-MEDIATED PHAGOCYTOSIS ASSAY FOR RELIABLY MEASURING UPTAKE OF AGGREGATED PROTEINS | BIOGEN INTERNATIONAL NEUROSCIENCE GMBH (CH) | 2017-09-21 | — | — | WO | claimed |
| US-11780834-B2 | Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3- yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use | GENENTECH, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| EP-4063858-A1 | ANTIBODY-DEPENDENT CELL-MEDIATED PHAGOCYTOSIS ASSAY FOR RELIABLY MEASURING UPTAKE OF AGGREGATED PROTEINS | Biogen International Neuroscience GmbH (CH) | 2022-09-28 | — | — | EP | disclosed |
| US-11340225-B2 | Antibody-dependent cell-mediated phagocytosis assay for reliably measuring uptake of aggregated proteins | BIOGEN INTERNATIONAL NEUROSCIENCE GMBH (CH) | 2022-05-24 | — | — | US | disclosed |
| EP-3430397-B1 | ANTIBODY-DEPENDENT CELL-MEDIATED PHAGOCYTOSIS ASSAY FOR RELIABLY MEASURING UPTAKE OF AGGREGATED PROTEINS | BIOGEN INT NEUROSCIENCE GMBH (CH) | 2022-02-23 | — | — | EP | disclosed |
| CN-112638405-A | Inhibition of RIP kinase for treatment of neurodegenerative diseases | 约翰斯霍普金斯大学 | 2021-04-09 | — | — | CN | disclosed |
| US-20190079077-A1 | ANTIBODY-DEPENDENT CELL-MEDIATED PHAGOCYTOSIS ASSAY FOR RELIABLY MEASURING UPTAKE OF AGGREGATED PROTEINS | BIOGEN INTERNATIONAL NEUROSCIENCE GMBH (CH) | 2019-03-14 | — | — | US | disclosed |
| EP-3430397-A1 | ANTIBODY-DEPENDENT CELL-MEDIATED PHAGOCYTOSIS ASSAY FOR RELIABLY MEASURING UPTAKE OF AGGREGATED PROTEINS | Biogen International Neuroscience GmbH (CH) | 2019-01-23 | — | — | EP | disclosed |
| US-7262262-B2 | Resin composition for toner and toner | SEKISUI CHEMICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| US-20050245694-A1 | Resin composition for tonor, and toners | MITSUI CHEMICALS, INC. (JP) | 2005-11-03 | — | — | US | disclosed |
| EP-1550915-A1 | RESIN COMPOSITION FOR TONOR, AND TONERS | Sekisui Chemical Co., Ltd. (JP) | 2005-07-06 | — | — | EP | disclosed |
| US-20040132920-A1 | Resin composition for toner and toner | MITSUI CHEMICALS, INC. (JP) | 2004-07-08 | — | — | US | disclosed |
| EP-1385062-A1 | RESIN COMPOSITION FOR TONER AND TONER | SEKISUI CHEMICAL CO., LTD. (JP) | 2004-01-28 | — | — | EP | disclosed |
| US-5648473-A | GLYCOSYLATION IN SOLVENT | ELI LILLY AND COMPANY (US) | 1997-07-15 | — | — | US | disclosed |
| US-5594124-A | REACTING ALPHA-ANOMER ENRICHED 2,2-DIFLUOROCARBOHYDRATE WITH AT LEAST THREE MOLAR EQUIVALENTS OF PROTECTED NUCLEOBASE IN LOW FREEZING INERT SOLVENT | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |