Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HEXA | P06865 | 6/20 | 0.71 |
| ▸ | HEXB | P07686 | 6/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | AHR | P35869 | 1/20 | 0.65 |
| ▸ | RAD52 | P43351 | 1/20 | 0.65 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.65 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.63 |
| ▸ | OGA | O60502 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | HK1 | P19367 | 1/20 | 0.60 |
| ▸ | APEX1 | P27695 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22683219 | 0.97 | HEXA (0.73) | HEXAHEXBKMT2APOLBMEN1 | |
| SCHEMBL9034219 | 0.89 | HEXA (0.69) | HEXAHEXBKMT2APOLBMEN1 | |
| SCHEMBL9626265 | 0.89 | HEXA (0.83) | HEXAHEXBKMT2APOLBMEN1 | |
| SCHEMBL9625779 | 0.87 | HEXA (0.81) | HEXAHEXBKMT2APOLBMEN1 | |
| SCHEMBL9625395 | 0.87 | HEXA (0.81) | HEXAHEXBKMT2APOLBMEN1 | |
| SCHEMBL9625535 | 0.87 | HEXA (0.81) | HEXAHEXBKMT2APOLBMEN1 | |
| SCHEMBL9625518 | 0.87 | HEXA (0.81) | HEXAHEXBKMT2APOLBMEN1 | |
| SCHEMBL21450705 | 0.84 | HEXA (0.73) | HEXAHEXBKMT2APOLBMEN1 | |
| SCHEMBL31622484 | 0.83 | MAPT (0.62) | KMT2AMEN1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL5312972 | 0.83 | MAPT (0.62) | KMT2AMEN1SMN1; SMN2MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118065-B1 | Substituted 1H-benz[de]isoquinoline-1,3-diones | COUNCIL SCIENT IND RES (IN) | 2013-08-14 | — | — | EP | disclosed |
| EP-2118065-A1 | NOVEL SUBSTITUTED 1H-BENZ ÝDE¨ISOQUINOLINE-1, 3 -DIONES | Council of Scientific & Industrial Research (IN) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008084496-A1 | NOVEL SUBSTITUTED 1H-BENZ [DE] ISOQUINOLINE-1, 3 -DIONES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2008-07-17 | — | — | WO | disclosed |