Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 7/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4130090 | 0.88 | ALDH1A1 (0.46) | KMT2AALDH1A1POLBBACE1USP2 | |
| SCHEMBL28811955 | 0.84 | SRPK1 (0.39) | KDM4EALDH1A1BACE1USP2LMNA | |
| SCHEMBL12522123 | 0.80 | ABL1 (0.42) | BACE1LMNA | |
| SCHEMBL4139048 | 0.79 | MOK (0.47) | BTK | |
| SCHEMBL4134689 | 0.79 | HTR2C (0.48) | MAPK1BACE1LMNA | |
| SCHEMBL4138177 | 0.78 | ADORA2A (0.48) | KMT2AALDH1A1BACE1LMNA | |
| SCHEMBL4448750 | 0.77 | KMT2A (0.39) | KDM4EMEN1KMT2AALDH1A1POLB | |
| SCHEMBL4145895 | 0.77 | ADORA2A (0.48) | BACE1LMNA | |
| SCHEMBL4148270 | 0.76 | POLB (0.44) | MEN1KMT2APOLBBACE1 | |
| SCHEMBL4145474 | 0.75 | ABL1 (0.48) | KDM4EBACE1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134695-A1 | INHIBITORS OF THE HEDGEHOG PATHWAY | Exelixis, Inc. (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008112913-A1 | INHIBITORS OF THE HEDGEHOG PATHWAY | EXELIXIS, INC. (US) | 2008-09-18 | — | — | WO | disclosed |