Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 13/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.43 |
| ▸ | DRD5 | P21918 | 4/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.43 |
| ▸ | DRD1 | P21728 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL478090 | 0.87 | PSEN1 (0.53) | P2RY14TMEM97SIGMAR1DRD5ADRA2B | |
| SCHEMBL3658054 | 0.85 | P2RY14 (0.42) | P2RY14PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4457444 | 0.80 | PSEN1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL478025 | 0.79 | PSEN1 (0.53) | P2RY14TMEM97SIGMAR1DRD5ADRA2B | |
| SCHEMBL478232 | 0.78 | PSEN1 (0.50) | P2RY14TMEM97SIGMAR1ADRB3PSEN1 | |
| SCHEMBL4449081 | 0.78 | P2RY14 (0.46) | P2RY14TMEM97SIGMAR1DRD5ADRA2B | |
| SCHEMBL478077 | 0.78 | PSEN1 (0.69) | P2RY14TMEM97SIGMAR1DRD5ADRA2B | |
| SCHEMBL12012810 | 0.78 | PSEN1 (0.56) | P2RY14TMEM97SIGMAR1DRD5ADRA2B | |
| SCHEMBL2897136 | 0.77 | PSEN1 (0.45) | P2RY14DRD5DRD1DRD3PSEN1 | |
| SCHEMBL12013338 | 0.76 | CTSL (0.46) | P2RY14TMEM97SIGMAR1DRD5ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306392-A1 | GSM INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306392-A1 | GSM INTERMEDIATES | BACE1, GSAP, PSEN1 | P2RY14 3481/4885TMEM97 2333/4885SIGMAR1 4269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.