Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A1 | P43005 | 1/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 3/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL589861 | 1.00 | SLC1A1 (0.46) | SLC1A1P4HTMLTA4HCNR1SIRT6 | |
| SCHEMBL4441919 | 0.87 | SLC1A1 (0.57) | SLC1A1P4HTMLTA4HCNR1TACR1 | |
| SCHEMBL2059074 | 0.87 | SLC1A1 (0.57) | SLC1A1LTA4HTACR1 | |
| SCHEMBL2389104 | 0.87 | SLC1A1 (0.57) | SLC1A1LTA4HTACR1 | |
| SCHEMBL1279255 | 0.87 | SLC1A1 (0.57) | SLC1A1LTA4HTACR1 | |
| Hydrochloric Acid SCHEMBL5487502 | 0.86 | SLC1A1 (0.56) | SLC1A1LTA4HTACR1 | |
| Hydrochloric Acid SCHEMBL5487507 | 0.86 | SLC1A1 (0.56) | SLC1A1LTA4HTACR1 | |
| Hydrochloric Acid SCHEMBL29886043 | 0.86 | SLC1A1 (0.56) | SLC1A1LTA4HTACR1 | |
| Hydrochloric Acid SCHEMBL5926216 | 0.78 | SLC1A1 (0.48) | SLC1A1LTA4H | |
| SCHEMBL24103465 | 0.76 | MAPT (0.52) | SLC1A1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029554-B1 | PYRAZINE DERIVATIVES AND USES THEREOF IN RENAL MONITORING | MEDIBEACON LLC (US) | 2014-03-19 | — | — | EP | disclosed |
| EP-2029554-A1 | PYRAZINE DERIVATIVES AND USES THEREOF IN RENAL MONITORING | Mallinckrodt, Inc. (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007149479-A1 | PYRAZINE DERIVATIVES AND USES THEREOF IN RENAL MONITORING | MALLINCKRODT INC. (US) | 2007-12-27 | — | — | WO | disclosed |