Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | AVPR1A | P37288 | 10/20 | 0.57 |
| ▸ | AVPR2 | P30518 | 9/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437875 | 0.99 | ALDH1A1 (0.71) | ALDH1A1MEN1HTTKMT2ATDP1 | |
| SCHEMBL239593 | 0.99 | ALDH1A1 (0.71) | ALDH1A1MEN1HTTKMT2ATDP1 | |
| SCHEMBL241405 | 0.89 | ALDH1A1 (0.67) | ALDH1A1MEN1HTTKMT2ATDP1 | |
| SCHEMBL240255 | 0.89 | ALDH1A1 (0.67) | ALDH1A1MEN1HTTKMT2ATDP1 | |
| SCHEMBL240649 | 0.89 | ALDH1A1 (0.67) | ALDH1A1MEN1HTTKMT2ATDP1 | |
| SCHEMBL241406 | 0.89 | ALDH1A1 (0.67) | ALDH1A1MEN1HTTKMT2ATDP1 | |
| SCHEMBL240257 | 0.89 | ALDH1A1 (0.67) | ALDH1A1MEN1HTTKMT2ATDP1 | |
| SCHEMBL238799 | 0.88 | ALDH1A1 (0.66) | ALDH1A1MEN1HTTKMT2ATDP1 | |
| SCHEMBL240256 | 0.88 | ALDH1A1 (0.66) | ALDH1A1MEN1HTTKMT2ATDP1 | |
| SCHEMBL1305931 | 0.87 | ALDH1A1 (0.65) | ALDH1A1MEN1HTTKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010479-A1 | 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS | High Point Pharmaceuticals, LLC (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007115935-A1 | 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2007-10-18 | — | — | WO | disclosed |