Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.47 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727586 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL4442928 | 0.96 | ZDHHC20 (0.47) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| Trimethylammonium SCHEMBL27513150 | 0.92 | ZDHHC20 (0.44) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| Acetic Acid SCHEMBL3920204 | 0.92 | ZDHHC20 (0.44) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| Trimethylammonium SCHEMBL27802499 | 0.90 | ZDHHC20 (0.43) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| Trimethylammonium SCHEMBL27802498 | 0.90 | ZDHHC20 (0.43) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL5682114 | 0.85 | ZDHHC20 (0.55) | ZDHHC20ZDHHC2TSHRHDAC3HDAC1 | |
| SCHEMBL3262448 | 0.83 | ZDHHC20 (0.63) | ZDHHC20ZDHHC2TSHRHDAC3HDAC1 | |
| SCHEMBL20355985 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL4442951 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051861-A1 | POROUS MEMBRANE AND RECORDING MEDIA COMPRISING SAME | FUJIFILM Manufacturing Europe B.V. (NL) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008016303-A1 | POROUS MEMBRANE AND RECORDING MEDIA COMPRISING SAME | FUJIFILM MANUFACTURING EUROPE B.V. (NL) | 2008-02-07 | — | — | WO | disclosed |