Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | NPC1 | O15118 | 2/20 | 0.77 |
| ▸ | RAB9A | P51151 | 2/20 | 0.77 |
| ▸ | APP | P05067 | 3/20 | 0.71 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.70 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.66 |
| ▸ | FLT3 | P36888 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | CTSL | P07711 | 1/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4449583 | 1.00 | MAPT (0.77) | MAPTMEN1MAPK1KMT2ANPC1 | |
| SCHEMBL30912311 | 0.90 | MAPT (0.69) | MAPTMEN1MAPK1KMT2ANPC1 | |
| SCHEMBL29225565 | 0.90 | MAPT (0.69) | MAPTMEN1MAPK1KMT2ANPC1 | |
| SCHEMBL29225566 | 0.90 | MAPT (0.69) | MAPTMEN1MAPK1KMT2ANPC1 | |
| SCHEMBL30138822 | 0.90 | MAPT (0.78) | MAPTMEN1MAPK1KMT2ANPC1 | |
| SCHEMBL5138233 | 0.89 | MAPT (0.71) | MAPTMEN1MAPK1KMT2ANPC1 | |
| SCHEMBL5138238 | 0.89 | MAPT (0.71) | MAPTMEN1MAPK1KMT2ANPC1 | |
| SCHEMBL634357 | 0.87 | MAPT (1.00) | MAPTMEN1MAPK1KMT2ANPC1 | |
| SCHEMBL634358 | 0.87 | MAPT (1.00) | MAPTMEN1MAPK1KMT2ANPC1 | |
| SCHEMBL5084271 | 0.87 | APP (0.82) | MAPTMEN1MAPK1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090182058-A1 | Novel Chalcone Derivatives With Antimitotic Activity | UNIVERSITE JOSEPH FOURIER GRENOBLE I (FR) | 2009-07-16 | — | — | US | claimed |
| US-20090182058-A1 | Novel Chalcone Derivatives With Antimitotic Activity | UNIVERSITE JOSEPH FOURIER GRENOBLE I (FR) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090182058-A1 | Novel Chalcone Derivatives With Antimitotic Activity | ABCE1, CCNE1, FOXM1 | MAPT 4453/4885MEN1 2708/4885MAPK1 1125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.