SCHEMBL4449899

SCHEMBL4449899

C(=Cc1ccc2occc2c1)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.59
RELA Q04206 1/20 0.55
IDO1 P14902 2/20 0.44
CTNNB1 P35222 1/20 0.44
WNT3A P56704 1/20 0.44
PLG P00747 1/20 0.42
PLAU P00749 1/20 0.42
PLAT P00750 1/20 0.42
KLK1 P06870 1/20 0.42
ADORA3 P0DMS8 1/20 0.42
NFE2L2 Q16236 2/20 0.41
CYP19A1 P11511 2/20 0.41
MAOA P21397 2/20 0.41
MAOB P27338 2/20 0.41
ADORA2A P29274 1/20 0.41
ADORA1 P30542 1/20 0.41
CYP1A1 P04798 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP1B1 Q16678 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11769294 0.85 RELA (0.55) CYP2A6RELAPLGPLAUPLAT
SCHEMBL11769290 0.85 RELA (0.55) CYP2A6RELAPLGPLAUPLAT
SCHEMBL17821821 0.83 CYP2A6 (0.61) CYP2A6IDO1CTNNB1WNT3AADORA2A
SCHEMBL17821819 0.83 CYP2A6 (0.61) CYP2A6IDO1CTNNB1WNT3AADORA2A
SCHEMBL709090 0.80 CYP2A6 (0.50) CYP2A6
SCHEMBL709089 0.80 CYP2A6 (0.50) CYP2A6
SCHEMBL15676441 0.79 CYP2A6 (0.61) CYP2A6CTNNB1WNT3A
SCHEMBL7896088 0.78 CYP2A6 (0.51) CYP2A6IDO1CTNNB1WNT3ANFE2L2
SCHEMBL28912228 0.78 CYP3A4 (0.54) CYP2A6RELACTNNB1WNT3AMAOB
SCHEMBL29593149 0.78 CYP3A4 (0.54) CYP2A6RELACTNNB1WNT3AMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113105496-B Method for synthesizing o-alkenylphenol derivative through nickel-catalyzed ring opening of benzofuran 华南理工大学 2022-06-14 CN disclosed
CN-113105496-A Method for synthesizing o-alkenylphenol derivative through nickel-catalyzed ring opening of benzofuran 华南理工大学 2021-07-13 CN disclosed
EP-2121648-A2 S1P RECEPTOR MODULATING COMPOUNDS AND USE THEREOF EPIX Pharmaceuticals, Inc. (US) 2009-11-25 EP disclosed
WO-2007109334-A2 SIP RECEPTOR MODULATING COMPOUNDS AND USE THEREOF EPIX DELAWARE, INC. (US) 2007-09-27 WO disclosed