Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461761 | 0.86 | MAPT (0.49) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4462859 | 0.80 | PRMT5 (0.54) | PRMT5WDR77ALDH1A1MEN1KMT2A | |
| SCHEMBL4324300 | 0.78 | KDM4E (0.57) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4332806 | 0.76 | POLB (0.44) | PRMT5WDR77ALDH1A1MEN1KMT2A | |
| SCHEMBL4332906 | 0.75 | PRMT5 (0.49) | PRMT5WDR77ALDH1A1MEN1KMT2A | |
| SCHEMBL4454123 | 0.73 | KDM4E (0.51) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4326742 | 0.72 | MAPT (0.78) | PRMT5WDR77ALDH1A1MEN1KMT2A | |
| SCHEMBL4326738 | 0.72 | MAPT (0.78) | PRMT5WDR77ALDH1A1MEN1KMT2A | |
| SCHEMBL7318722 | 0.70 | HPGD (0.69) | PRMT5WDR77ALDH1A1MEN1KMT2A | |
| SCHEMBL7318717 | 0.70 | HPGD (0.69) | PRMT5WDR77ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521062-B2 | Thiosemicarbazones as anti-virals and immunopotentiators | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2009-04-21 | — | — | US | disclosed |