Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Irinotecan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 known ✓ | P11387 | 6/20 | 0.77 |
| ▸ | GLA | P06280 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.99 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.99 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.99 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.99 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.99 |
| ▸ | MMP1 | P03956 | 1/20 | 0.99 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.99 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.99 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.99 |
| ▸ | ACHE | P22303 | 1/20 | 0.99 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.99 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Irinotecan SCHEMBL663859 | 1.00 | GLA (1.00) | GLAGAAKDM4EALDH1A1LMNA | |
| Irinotecan SCHEMBL16447653 | 1.00 | GLA (1.00) | GLAGAAKDM4EALDH1A1LMNA | |
| Irinotecan SCHEMBL29363805 | 1.00 | GLA (1.00) | GLAGAAKDM4EALDH1A1LMNA | |
| Irinotecan SCHEMBL4033 | 1.00 | GLA (1.00) | GLAGAAKDM4EALDH1A1LMNA | |
| Irinotecan SCHEMBL359364 | 0.99 | PAX8 (1.00) | GLAGAAKDM4EALDH1A1LMNA | |
| Irinotecan SCHEMBL572716 | 0.99 | PAX8 (1.00) | GLAGAAKDM4EALDH1A1LMNA | |
| Irinotecan SCHEMBL30822976 | 0.99 | PAX8 (1.00) | GLAGAAKDM4EALDH1A1LMNA | |
| Irinotecan SCHEMBL29359605 | 0.99 | PAX8 (1.00) | GLAGAAKDM4EALDH1A1LMNA | |
| Irinotecan SCHEMBL12313065 | 0.99 | GLA (1.00) | GLAGAAKDM4EALDH1A1LMNA | |
| Irinotecan SCHEMBL131381 | 0.99 | GLA (1.00) | GLAGAAKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2854818-A2 | CHEMICAL SUPPRESSORS OF NEUROTOXICITY IN SYNUCLEINOPATHIC DISEASES | Oxalys Pharmaceuticals (CA) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013179144-A2 | CHEMICAL SUPPRESSORS OF NEUROTOXICITY IN SYNUCLEINOPATHIC DISEASES | OXALYS PHARMACEUTICALS (CA) | 2013-12-05 | — | — | WO | disclosed |
| US-7625860-B2 | Methods and compositions for modulating cell proliferation and cell death | AU JESSIE L-S | 2009-12-01 | — | — | US | disclosed |
| US-20050171016-A1 | Thrombospondin-2 and uses thereof | THE GENERAL HOSPITAL CORPORATION, A MASSACHUSETTS CORPORATION | 2005-08-04 | — | — | US | disclosed |
| EP-1206234-A4 | METHODS AND COMPOSITIONS FOR MODULATING CELL PROLIFERATION AND CELL DEATH | AU JESSIE L S (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1171151-A4 | THROMBOSPONDIN-2 AND USES THEREOF | GEN HOSPITAL CORP (US) | 2004-08-04 | — | — | EP | disclosed |
| US-20040010001-A1 | Methods and compositions for modulating cell proliferation and cell death | AU JESSIE L-S (US) | 2004-01-15 | — | — | US | disclosed |
| US-6599912-B1 | Administering cytotoxic agent and suramin to inhibit cell proliferation and tumor cell growth | AU JESSIE L-S (US) | 2003-07-29 | — | — | US | disclosed |
| WO-2002078606-A2 | THROMBOSPONDIN-2 AND USES THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |
| WO-2000074634-A9 | METHODS AND COMPOSITIONS FOR MODULATING CELL PROLIFERATION AND CELL DEATH | AU JESSIE L S (US) | 2002-09-26 | — | — | WO | disclosed |
| US-20020119921-A1 | Thrombospondin-2 and uses thereof | THE GENERAL HOSPITAL CORPORATION | 2002-08-29 | — | — | US | disclosed |
| EP-1206234-A2 | METHODS AND COMPOSITIONS FOR MODULATING CELL PROLIFERATION AND CELL DEATH | Au, Jessie L.S. (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1171151-A1 | THROMBOSPONDIN-2 AND USES THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000074634-A2 | METHODS AND COMPOSITIONS FOR MODULATING CELL PROLIFERATION AND CELL DEATH | AU JESSIE L S (US) | 2000-12-14 | — | — | WO | disclosed |
| WO-2000057899-A1 | THROMBOSPONDIN-2 AND USES THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2000-10-05 | — | — | WO | disclosed |