Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4324495 | 0.87 | ALDH1A1 (0.47) | TSHRMAPTLMNAALDH1A1HSD17B10 | |
| SCHEMBL29196257 | 0.85 | TSHR (0.59) | TSHRMAPTLMNAALDH1A1HSD17B10 | |
| SCHEMBL11247916 | 0.84 | TSHR (0.62) | TSHRMAPTLMNAALDH1A1HSD17B10 | |
| SCHEMBL23879261 | 0.82 | MRGPRX4 (0.49) | TSHRMAPTALDH1A1HSD17B10USP2 | |
| SCHEMBL30452297 | 0.82 | MRGPRX4 (0.49) | TSHRMAPTALDH1A1HSD17B10USP2 | |
| SCHEMBL23773427 | 0.82 | TSHR (0.68) | TSHRMAPTLMNAALDH1A1HSD17B10 | |
| SCHEMBL17083285 | 0.81 | TSHR (0.54) | TSHRMAPTLMNAALDH1A1HSD17B10 | |
| SCHEMBL29196223 | 0.81 | TSHR (0.54) | TSHRMAPTLMNAALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL17077453 | 0.80 | TSHR (0.53) | TSHRMAPTLMNAALDH1A1HSD17B10 | |
| SCHEMBL17077586 | 0.80 | TSHR (0.53) | TSHRMAPTLMNAALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027123-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007134259-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-11-22 | — | — | WO | disclosed |