SCHEMBL4450895

SCHEMBL4450895

C[C@H](NCc1ccc(OCCc2cccc(F)c2)cc1)C(N)=O

nearest known ligand 0.80

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 0.80
MAOA P21397 3/20 0.80
SCN9A Q15858 2/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1070405 1.00 MAOB (0.80) MAOBMAOASCN9A
SCHEMBL8640659 0.96 MAOB (0.74) MAOBMAOASCN9A
SCHEMBL8636182 0.94 MAOB (0.78) MAOBMAOASCN9A
SCHEMBL8637846 0.91 MAOB (0.72) MAOBMAOASCN9A
Hydrochloric Acid SCHEMBL8636518 0.90 MAOB (0.71) MAOBMAOASCN9A
Safinamide SCHEMBL194169 0.89 MAOB (1.00) MAOBMAOASCN9A
Safinamide SCHEMBL29358109 0.89 MAOB (1.00) MAOBMAOASCN9A
Safinamide SCHEMBL69350 0.89 MAOB (1.00) MAOBMAOASCN9A
Safinamide SCHEMBL31174565 0.89 MAOB (1.00) MAOBMAOASCN9A
Safinamide SCHEMBL69351 0.89 MAOB (1.00) MAOBMAOASCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2070526-A1 \"Methods for treatment of Parkinson's disease\ Newron Pharmaceuticals S.p.A. (IT) 2009-06-17 EP claimed
US-20070093495-A1 Methods for treatment of parkinson's disease NEWRON PHARMACEUTICALS S.P.A. (IT) 2007-04-26 US claimed
EP-1613296-A2 METHODS FOR TREATMENT OF PARKINSON'S DISEASE Newron Pharmaceuticals S.p.A. (IT) 2006-01-11 EP claimed
WO-2004089353-A2 METHODS FOR TREATMENT OF PARKINSON'S DISEASE NEWRON PHARMACEUTICALS, S.P.A. (IT) 2004-10-21 WO claimed
US-9492410-B2 Methods for treatment of Parkinson's disease NEWRON PHARMACEUTICALS S.P.A. (IT) 2016-11-15 US disclosed
US-20150150833-A1 Methods For Treatment of Parkinson's Disease NEWRON PHARMACEUTICALS S.P.A. (IT) 2015-06-04 US disclosed
US-8901176-B2 Methods for treatment of Parkinson's disease NEWRON PHARMACEUTICALS, S.P.A. (IT) 2014-12-02 US disclosed
US-20130053368-A1 METHODS FOR TREATMENT OF PARKINSON'S DISEASE NEWRON PHARMACEUTICALS S.P.A (IT) 2013-02-28 US disclosed
US-8283380-B2 Methods for treatment of parkinson's disease NEWRON PHARMACEUTICALS S.P.A. (IT) 2012-10-09 US disclosed
EP-1613296-B1 METHODS FOR TREATMENT OF PARKINSON'S DISEASE NEWRON PHARM SPA (IT) 2009-07-01 EP disclosed
EP-2070526-A1 \"Methods for treatment of Parkinson's disease\ Newron Pharmaceuticals S.p.A. (IT) 2009-06-17 EP disclosed
US-20070093495-A1 Methods for treatment of parkinson's disease NEWRON PHARMACEUTICALS S.P.A. (IT) 2007-04-26 US disclosed
EP-1613296-A2 METHODS FOR TREATMENT OF PARKINSON'S DISEASE Newron Pharmaceuticals S.p.A. (IT) 2006-01-11 EP disclosed
WO-2004089353-A2 METHODS FOR TREATMENT OF PARKINSON'S DISEASE NEWRON PHARMACEUTICALS, S.P.A. (IT) 2004-10-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130053368-A1 METHODS FOR TREATMENT OF PARKINSON'S DISEASE MAOB, MAOA, SNCA MAOB 1/4885MAOA 2/4885SCN9A 2416/4885
US-20070093495-A1 Methods for treatment of parkinson's disease MAOB, MAOA, SNCA MAOB 1/4885MAOA 2/4885SCN9A 2416/4885
US-20150150833-A1 Methods For Treatment of Parkinson's Disease MAOB, MAOA, SNCA MAOB 1/4885MAOA 2/4885SCN9A 2416/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.