Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1894600 | 0.89 | PDE10A (0.40) | PDE10AMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL4450943 | 0.86 | CYP3A4 (0.39) | PDE10AMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL4016370 | 0.80 | F10 (0.38) | PDE10AMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL1891376 | 0.80 | PDE10A (0.40) | PDE10AMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL12994037 | 0.80 | PDE10A (0.40) | PDE10AMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL4013362 | 0.78 | MAPK1 (0.37) | PDE10ACYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL13625902 | 0.78 | ALDH1A1 (0.41) | PDE10AMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL1892239 | 0.78 | F10 (0.47) | PDE10AMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL1895965 | 0.76 | F10 (0.43) | PDE10AMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL4013013 | 0.76 | PDE10A (0.43) | PDE10AMEN1KMT2ACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133970-A1 | CRYSTALLINE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-05 | — | — | WO | disclosed |