Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2417968 | 0.78 | KMT2A (0.49) | ALDH1A1SMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL7506759 | 0.75 | GAA (0.47) | TSHRALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL1039579 | 0.74 | POLB (0.66) | TSHRALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL207698 | 0.73 | NPC1 (0.44) | ALDH1A1SMN1; SMN2MAPTPOLBNPC1 | |
| SCHEMBL3561735 | 0.73 | DAO (0.43) | TSHRALDH1A1SMN1; SMN2POLBNPC1 | |
| SCHEMBL1446966 | 0.73 | MEN1 (0.57) | TSHRALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL7439559 | 0.72 | GAA (0.55) | ALDH1A1SMN1; SMN2NPC1RAB9ANAPRT | |
| Hydrochloric Acid SCHEMBL5353440 | 0.72 | NPC1 (0.43) | ALDH1A1SMN1; SMN2MAPTPOLBNPC1 | |
| SCHEMBL207697 | 0.72 | MEN1 (0.40) | ALDH1A1SMN1; SMN2MAPTPOLBNPC1 | |
| SCHEMBL9850025 | 0.72 | ALOX5 (0.46) | TSHRALDH1A1SMN1; SMN2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544700-B2 | Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein JunKinases | LABORATOIRES SERONO SA (CH) | 2009-06-09 | — | — | US | disclosed |
| EP-1218374-A1 | PHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001023378-A1 | PHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-05 | — | — | WO | disclosed |