Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4453859 | 0.82 | CTSK (1.00) | CTSKCTSS | |
| SCHEMBL4446022 | 0.82 | CTSK (1.00) | CTSKCTSS | |
| SCHEMBL4442260 | 0.81 | CTSK (1.00) | CTSKCTSS | |
| SCHEMBL4446363 | 0.81 | CTSK (1.00) | CTSKCTSS | |
| SCHEMBL4446357 | 0.79 | CTSK (1.00) | CTSKCTSS | |
| SCHEMBL4444428 | 0.79 | CTSK (1.00) | CTSKCTSS | |
| SCHEMBL4442137 | 0.78 | CTSK (0.66) | CTSKCTSS | |
| SCHEMBL4444344 | 0.78 | CTSK (1.00) | CTSKCTSS | |
| SCHEMBL4445034 | 0.77 | CTSK (1.00) | CTSKCTSS | |
| SCHEMBL5548112 | 0.76 | CTSK (0.93) | CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589095-B2 | 4-phenyl-pyrimidine-2-carbonitrile derivatives | N.V. ORGANON (NL) | 2009-09-15 | — | — | US | disclosed |
| US-20080090813-A1 | 4-Phenyl-Pyrimidine-2-Carbonitrile Derivatives | Cai, Jiaqiang | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090813-A1 | 4-Phenyl-Pyrimidine-2-Carbonitrile Derivatives | P2RY4, P2RX4, P2RY1 | CTSK 1852/4885CTSS 2645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.